User blog comment:Hulk10/Peter and Mary Jane Watson/@comment-24812000-20160622002958

I actually feel like something will happen. The current ASM arc features her, and in a recent issue of Spider-Man/Deadpool (#5 I think), Peter met Mephisto for the first time since One More Day. He said he was the "source of all his recent problems", without saying exactly what that was. Peter thought about it, but Mephisto obviously still remembers. So who knows, maybe they can finally be happy again.