User blog comment:Gcheung28/Spider-Man vs. Wolverine/@comment-4651179-20140423011850/@comment-4651179-20140505011522

Spider-Man is strong enough to hit him, Spider-Man has been able to easily lift cars with a finger. And although his skeleton is laced with Adamantium, his brain would still hit against it, what would cause a concussion, and fainting.

In Avenging Spider-Man #16, he knocked out Wolverine easily: Images here and here.

One more thing! *smacks you in the head* In the comics, Hulk has been able to knock out Wolverine.