User blog comment:MarvelFan2012/Questions and Answers about Spider-Man/@comment-3127363-20120729195438/@comment-5111260-20120729230040

Spider-Man's powers came directly from the Spider Bite. But Ezekiel had told him that the reason the spider had bit Peter was because it willingly passed on it's powers to Peter before dying.

So to tell the truth, Spider-Man is in no ways a mutant or naturally born with powers, he was just a normal person who had obtained powers from a spider that had bit him voluntarily, as Ezekiel had explained.