User blog comment:BIONICLEToa/Why can't Marvel have a main female role in their films?/@comment-1895174-20140320065414/@comment-1895174-20140321004317

I don't know about Spider-Woman. She has no supporting cast or notable villains to speak of, and is primarily a member of the Avengers or SHIELD. And too many people would be too confused as to how she's related to Spider-Man.

Plus, her most notable story is still Secret Invasion, and various people involved in the development of the MCU have put the kibosh on the Skrulls ever showing up.