User blog comment:Deadpool(Earth 616)/Who is Deadpool's arch enemy????/@comment-3127363-20120717232142

Ajax or Tray are the iones most closely related to his origins and the ones who have the most hate for him, although Ajax is dead now and Tray stands depressed and morally defeated since a while now. Taskmaster is not really his enemy as much as he is his friendly foe, just like Wolverine.