User blog comment:UltimateBub/Spider-Man's most menacing enemy (1962-1965)/@comment-1671874-20120825065932

In the short lived high school period I guess it'd have to be Doc Ock. and idk, I guess Sandman is the most powerful out of the original Sinister Six, so he'd probably win.

And a better question: which of the Sinister Six should appear in the next Spider-Man film? Hmm... why not a duo of Mysterio and Kraven? Try and play off Mysterio in Calypso's place? It wouldn't be the weirdest thing from a comic-movie switch...