User blog comment:The Many-Angled One/I Know What Cyclops Did Last Summer/@comment-2204174-20151228181503/@comment-16461120-20151229082337

I think you can look at the differences from a chemistry standpoint and find that it's a toxicity thing that's not inconsistent with real world applications. For example, there is arsenic in apple juice and coming into contact with a little bit of arsenic does not kill you, but exposure to a dose the size of wandering global storm cloud certainly would.

In terms of other points, The states that some of the Dark Riders were Inhumans powered by Terrigenesis and then altered by Apocalypse, so that would make them Mutate/Inhuman hybrids, not Mutant/Inhuman hybrids; however, previous Mutant/Inhuman hybrids have generally shown that they aren't both things anyway. Their cross-bred genetics canceled out their x-genes and the Terrigen Mists then gave them powers via Terrigenesis. It's been that way for more than three decades, and thus I don't believe the current storyline is inconsistent there.