User blog comment:UltimateBub/Spider-Man's most menacing enemy (1962-1965)/@comment-2031194-20120829210854

Green Goblin has always been his biggest foe. Doc Ock is a pretty close second though. Out of the Sinister Six, in my opinion, Kraven, Mysterio, and Vulture wouldn't have much of a chance of winning. Electro could fry everybody if he got contact, Doc Ock is a super genius with multiple arms, but I'd pick Sandman, seeing as how he's near invulnerable (as long as nobody has a vacuum cleaner handy!). He'd just cover everyone in sand and suffocate them by flooding their lungs with sand. If he's not in the "smashing people with giant, granite fists" mood that is, lol.