User blog comment:UltimateBub/Spider-Man's most menacing enemy (1962-1965)/@comment-5364175-20120823134502

Definatly Green Goblin! He's Spidey's arch enemy!

As for who would win, I'd say Sandman, cause he can turn into sand, so they can't hurt him, or he could turn into rock, or a sandstorm!