User blog comment:LoveWaffle/Amazing Spider-Man 2 Idea (because it's the hot thing to do)/@comment-4591819-20120828210828/@comment-1895174-20120828211550

I really doubt they'd limit themselves solely based on a video game. Also, Vulture was the planned villain for the canned Spider-Man 4, yet was one of the villains in the 2002 tie-in.