User blog comment:Mr. Xemnas/What year does 616 take place?/@comment-1751305-20130330022151/@comment-4651179-20130330025938

From Secret Invasion to Marvel NOW! passed one year (according to Indestructible Hulk #3). So by math, since Fantastic Four #1 to that issue, 13 years have passed.

I asked Tom Brevoort via Formspring if this is true, and he said yes. 4 years in our world are 1 year in the Marvel Universe.