User blog comment:20thCentFopp/Submariner vs. Doctor Doom: What Makes A Supervillain?/@comment-6731922-20131220035709/@comment-4651179-20131220063238

I think overall, Green Goblin is more Spider-Man's archnemesis. Although the most recent thing Otto did had a lot of impact, that doesn't change the fact Green Goblin caused a more damage to him, including the discovery of his identity, the murder of Gwen Stacy, and the Clone Saga, to name a few.

I personally can't think of many truly impactful events in Spider-Man's life orchestrated by Doc Ock, Aunt May's wedding is not as remembered as much as Gwen Stacy's "snap". Not to mention most of Octavius' notorious moments against Spider-Man were intended to either kill or defeat Spider-Man "once and for all", while Green Goblin's were meant to ruin Peter's life. I mean, until 2010, Otto apparently didn't consider Spider-Man a menace but a nuisance.

I mean, the Joker fights Batman because he wants to push him to his limits, Lex Luthor fights Superman to show superiority, Red Skull fights Captain America to finish a long-time enmity, the Mandarin fights Iron Man in order to show his alien tech magic is superior to technology, Magneto fights the X-Men because rhey differ ideologies, Doctor Doom fights the Fantastic Four because he wants to show he's superior to their leader. None of those enmities surfaced because the villain felt the hero was a fly in his oinment, but because he wants to show him he's superior. That's another reason why whenever I picture the nemesis of the Marvel Universe, I don't imagine Spider-Man against Doc Ock.

Dan Slott is like (paraphrasing) "Oh, yeah. Osborn killed Spidey's girlfriend but Octavius now wears Peter's body as a puppet," but like I said, Green Goblin's impact in Spider-Man's life has been more important than Octavius' in the last years. For an archenemy, to defeat a hero shouldn't mean killing him (like Otto did) but make him want to be dead (like Osborn has done).