User blog comment:ADour/First The Amazing Spider-Man 2 trailer debuts!/@comment-2031194-20131207012451/@comment-4651179-20131207032044

You could also consider the actual main influences used in the designs.

The Lizard was Ditko's Lizard without labcoat.

Electro takes cues from both the original and modern versions of Ultimate Electro.

Green Goblin seems to be a mix of Ultimate and Mainstream Green Goblin.

And Rhino is obviously based of Ultimate Rhino / R.H.I.N.O.. Although he seems to have an appearance a little bit more of a mech than a rhinoceros, there are still no shots clear enough to fully see Rhino's design.