Thread:Arawn 999/@comment-3406131-20150320132333/@comment-25192437-20150320173033

While it wasn't explicitly stated she was a Spider-Totem when she was alive, Spider-Verse establishes that anyone who has spider-powers and is connected to the Web of Life and Destiny is one regardless of how they got their powers.

In Amazing Spider-Man Vol 1 669, it's revealed that the "spider-flu" made from the Queen's mutagenic enzyme connects those infected to it to the Web of Life and simultaneously amplifies her own connection to it, which is how she was able to turn into a giant spider-monster. As the Queen herself puts it: "I feel you, all of you, reaching out along the web we all share." Furthermore, her enzyme amplifies the abilities of those who are already Spider-Totems as seen with Peter, Kaine, and Anya.

So, while the Queen isn't a Human/Spider Hybrid, she is a Spider-Totem.