User blog comment:Ultimate Heatblast/The Dark Knight Rises vs The Amazing Spider-Man/@comment-4591819-20120729165250/@comment-1895174-20120729194331

I don't doubt that Dr. Connors will appear in any sequels, but I don't think the Lizard itself will come back. If it does, it won't be the film's primary villain.

Other than that, I want to see Norman Osborn (Goblin optional) played by Jason Isaacs. Also, I feel Venom is an inevitability since this franchise uses the Ultimate Marvel version of Richard Parker, although I'm not exactly excited about seeing him on screen again. While some other villains like Scorpion, Carnage, and Doc Ock have something in the way of them coming to the screen (respectively: too similar to Lizard, can't be done without already doing Venom, and already been done before and pretty well), I could easily see Electro, Kraven, Shocker, etc. as a hired gun for Osborn in the sequels.