Board Thread:Questions and Answers/@comment-26184563-20140330234219/@comment-61022-20150603120149

"Adamantium Poisoning" technically is a misnomer, because the metal itself is not really poisoning him, it's the environment around him.

In Wolverine's case he suffers from this "poisoning" because it encases his entire skeleton. The metal blocks the production of white blood cells, which are created in bone marrow. Wolverine's healing factor compensated for this by regenerating white blood cells independent from the usual biological process that anyone else would. Hence why when his healing factor was not working he was in effect "poisoned", as white blood cells are anti-bodies that protect the body from illness. As such, without his healing factor, his body's natural process of creating white blood cells that is blocked by the metal on his bones. It's not the metal itself that is poisoning him. He is really suffering from a lack of an immune system and outside pathogens making him sick, much in the same way someone with a severe and untreated case of AIDS.

Laura wouldn't have the same problem because the metal does not coat her entire body. Much in the same way as Bullseye doesn't have the same problem (he has Adamantium fused on his spine) or most others with Adamantium bonding.