This type of post was done before by @Grey.

But there the subject is more specific.

For a notable fact, Every villain( atleast in my knowledge) has some motives to do what he does, except some psychopaths like Norman(Kinda over the years), Bullseye, Cletus

But there are many who has a personal or occasional rivalry with the protagonists.

tHaNoS hAD uNdERstAndAbLe motIvEs hE waNTeD tO sAvE tHe uNiVErse

Are we talking comics or movies?

I think both.🤔😅