I think we need Pheonix empowered Apocalypse weilding the infinite gauntle combined with the crimson gem of Cytorak. All the while he reads from the Darkholme to utilise the Mykran crystal to aptly manipulate cosmic cube into bestowing him the power of the Odin force. Then, he will make will recruit Thanos as the horsemen of death, ghost rider as the horsement of pestilence, Galactus as the horsemen of famine, and Magus as the horsemen of war.
Then while he weilds Mjolnir, he'll pop his bone claws and cling to a wall with his new found spider powers. As he climbs the fabric of reality he'll inject himself with the ultimate Gamma formular to connect to the One Below all. Once he does that he'll marry the goblin force and eat the living tribunal for dinner.
On their honey moon, he'll hang out with the celestials and slay them all with Captain America's shield. The watchers will cry from a far and leave to a new dimension. The one above all will offer a round of applause and step down.
Then as Apocalypse sits on the internal thrown of the multiverse, he'll fight and be slain by the one true omnipotent force of the multiverse, Squirrel girl.