Mystique wins with low to mid difficulty

Mystique. More experience, more versatility, equal skill. She can also shape shift pretty wildly, like giving herself tendrils, or all of a sudden she has the head of a shark. Psylocke and gambit both have stated that fighting mystique is unpredictable and frustrating.

Psylocke only one through telepathy. Gambit was easily overcome by her. She killed fantomex once, and he has since stated its a fight hed prefer to avoid

Black widow doesnt have any advantages that mystique doesnt also have, and mystique just has a lot more

Mystique

Mystique takes the cake. Has more in her toolbox than Natasha that would be useful

I don't know, who do you think could seduce the other first?

That's a weird question

It is, but judging from the picture that seems to be Mystique's plan lol.

I mean mystique is bi, maybe she is

Mystique has a greater variety of options:

• Assume the form of a senior intelligence or law enforcement official, frame Black Widow for a serious crime or flag her as a security risk

• Disguise herself as friends and colleagues to get her when/if her guard is lowered or indulge in a little gaslighting and manipulation

• Directly assume the form of Black Widow and use this in various ways such as to damage her relationships and reputation to isolate her

• Direct assault

A Tough one but I choose Mystique