Dr Octopus and Mr Freeze both wanted to save humanity, but turned evil.
Both Bane and Kraven The Hunter want to be killed by the hero they fight.
Scorpion and Mad Hatter both mess with the mind of their heroes.
Carnage is pretty much Victor Zsasz with powers.
The Lizard and Man Bat were both working with animal DNA to help themselves, and become monsters.
What are your thoughts?