Agony was one of the five Life Foundation Symbiotes that were forcefully spawned from the Venom symbiote.
- Leslie Gesneria was a mercenary hired by the Life Foundation. In order to fulfill her role as a superhuman officer for the corporation's future utopia, she was granted one of the 5 symbiotes forcibly spawned from the Venom symbiote. Leslie was later killed by fellow former Life Foundation agent and host to one of Agony's siblings Scream, Donna Diego.
- Gemma Shin was Senator Peter Krane's deputy director of communications, she witnessed the Knull symbiote invasion where at one point she bonded to the Agony symbiote, who has now taken on the alias Agony.