Rhino's history is presumably similar to his Earth-616 counterpart's up to the point where Spider-Man first bonded to the Venom symbiote. When Spider-Man began killing criminals, Rhino and Spider-Man's other enemies reassembled the Sinister Six to stop him. Electro complained that he and Rhino were willing to go after Spider-Man for the Kingpin, but Kraven the Hunter convinced the pair to wait until a plan was made. Kraven pointed out that he would likely be dead if he had went after Spider-Man immediately. In the end, the criminals all agreed not to make a move until Kraven made a battle plan.
Spider-Man was lured out to a remote area by the Sinister Six. However, Spider-Man launched a sneak attack from underground and killed Mysterio. Rhino came charging in, but Spider-Man killed him with a single punch to the head.