She was the founder of L.A.S.S.E.S., a pseudo-school where teenagers were taught to become hired killers. During a gala with various sinister world government and corrupt figures in finance and industry to introduce the new L.A.S.S.E.S. graduate group, Lady Wells had all the wealthy patrons poisoned so that she could blackmail them for the antidote. Lady Wells was killed by Sharon Carter who shot her before a student of hers for whom the Black Widow, along with Sharon, had snuck into the gala in order to remove her from that milieu of murderous mercenaries.
Powers and Abilities