Appearing in "Opening Night"
Featured Characters:
- Spider-Man (Peter Parker) (Main story and recap)
- Mary Jane Watson (Main story and flashback) (Impersonates Melanie Daniels impersonating Invisible Woman)
Supporting Characters:
- NYPD
- Carlie Cooper
- Officer Rob (First appearance) (Unnamed)
- Numerous unnamed officers
- Melanie Daniels (First appearance) (Main story and flashback) (Impersonates Invisible Woman)
- Lizard (Curt Connors) (Main story and recap)
- Billy Connors (Main story and recap)
- Martha Connors
Antagonists
- Ludwig Rinehart / Mysterio / "Cage McKnight" (Quentin Beck) (Main story and recap)
"Kindred" 
- Connors' Robots (Only appearance; destruction)
- Electro (Francine Frye) (Main story and recap)
Other Characters:
- WCPD (Behind the scenes)
- "Mysterio" (Dr. Winhorst) (Corpse in recap)
- Kraven The Hunter (Sergei Kravinoff) (Recap)
- Arcade Industries (Recap)
- Hunterbots (Recap) (Controlled by The Great Hunt Participants)
- Arcade (Recap)
- Last Son of Kraven (Recap)
- Savage Six (Recap)
- Rhino (Aleksei Sytsevich) (Recap)
- Vulture (Adrian Toomes) (Recap)
- Puma (Thomas Fireheart) (Recap)
- Numerous unnamed New Yorkers
- Galactus (Poster and automaton)
- Avengers (Mentioned)
- Stark Industries (Mentioned)
- Numerous unnamed actors (Impersonate Mister Fantastic, Human Torch, The Thing, Doctor Doom, Silver Surfer, Atlanteans and Namor)
- Electro (Max Dillon) (Recap)
- Firelord (Pyreus Kril) (Mentioned)
- Daily Bugle (Mentioned)
- Terry Ford (First appearance)
- Abraham Lincoln (Mentioned)
- God (Yahweh) (Invoked)
- Black Cat (Felicia Hardy) (Recap)
- J. Jonah Jameson (Recap)
- Boomerang (Fred Myers) (Recap)
- May Parker-Jameson (Recap)
- Brett Hoskins (First appearance)
- Cage McKnight (Mentioned)
- Scarlet Spider (Ben Reilly) (Photo)
- Scarlet Spider (Kaine Parker) (Photo)
- Spider-Man (Miles Morales) (Photo)
- Superior Spider-Man (Otto Octavius) (Photo)
- Spider-Woman (Jess Drew) (Photo)
- Ghost-Spider (Gwen Stacy) (Photo)
- Silk (Cindy Moon) (Photo)
- Mayor Wilson Fisk (Behind the scenes)
- Syndicate (First appearance)
- Armadillo (Antonio Rodriguez) (Recap)
- Reed Richards (On-screen)
- Sue Storm (On-screen)
- Johnny Storm (On-screen)
- Ben Grimm (On-screen)
- Hulk (Bruce Banner) (On-screen)
- Vision (On-screen)
- Cable (Nathan Summers) (On-screen)
- Numerous unnamed oil workers
- Spider-Man (Miguel O'Hara)
Races and Species:
- Humans (Main story and flashback)
- Demons
- Centipedes
- Robots
- Androids (Recap)
- Cosmic Beings (Poster and automaton)
- Droids (Topical reference)
- Human-Reptile Hybrids (Main story and recap)
- Fish
- Rats
- Klyntar (Photo)
- Synthezoids (On-screen)
- Mutants (On-screen)
Locations:
- Prime Marvel Universe (Main story and flashback)
- Earth (Main story and flashback)
- United States of America (Main story and flashback)
- New York (Main story and flashback)
- Westchester County (Main story and recap)
- Ravencroft Institute (Recap)
- New York City (Main story and flashback)
- Connors' Warehouse
- Manhattan (Main story and flashback)
- Central Park (Recap)
- Midtown
- Theatre District
- Office of Chief Medical Examiner, Kips Bay (Mentioned)
- Greenwich Village (Recap)
- West Village (Recap)
- East Village (Main story and flashback)
- Bowery (Main story and flashback)
- Empire State University (Main story and flashback)
- Bowery (Main story and flashback)
- New York City Sewer System
- Kindred's cemetery
- Westchester County (Main story and recap)
- California (Main story and flashback)
- Los Angeles (Main story and flashback)
- Hollywood (Main story and flashback)
- Dolby Theatre (First appearance) (Only in flashback)
- Hollywood (Main story and flashback)
- Los Angeles (Main story and flashback)
- New York (Main story and flashback)
- Wundagore Mountain, Transia (Mentioned)
- Earth Orbit (On-screen)
- Van Allen Belts (On-screen)
- Pacific Ocean
- Astorania Oil Complex (Only appearance; destruction) (Unnamed)
- United States of America (Main story and flashback)
- Hell (Mentioned)
- Heavens (Invoked) (Only in flashback)
- Earth (Main story and flashback)
Items:
- Mysterio Suit (Main story and recap)
- Spider-Men's Suits and Web-Shooters (Main story and recap)
- Planetary Defense Shield (Recap)
- Kraven's Lion's Head Vest (Recap)
- Rhino Armor (Recap)
- Vulture's Wings (Recap)
- Hunter Killer (Behind the scenes in recap)
- Pretty Woman (Mentioned) (Topical reference)
- Inhibitor Chip (Behind the scenes)
- Black Cat's Suit (Recap)
- Scarlet Spider's Suit (Photo)
- Scarlet Spider's Suit (Photo)
- Superior Spider-Man's Suit (Photo)
- Spider-Woman's Suit (Photo)
- Lady Octopus' Tentacles
- Scorpia's Suit
- Beetle Armor MK IV
- Paste-Gun
- Cosmic Rays (On-screen)
- Iron Man Armor Model 13 (Hulkbuster Armor) (Drawing on-screen)
- Iron Man Armor Model 29 (Extremis Armor) (Drawing on-screen)
- Iron Man Armor Model 11 (War Machine Armor) (Drawing on-screen)
- Iron Man Armor Model 4 (Drawing on-screen)
- Iron Man Armor Model CE1 (Drawing on-screen)
- Techno-Organic Virus (On-screen)
- Spider-Man's 2099 Suit
Vehicles:
- Marvel-1 (On-screen) (Unnamed)
Events:
Synopsis for "Opening Night"
Peter cannot accompany Mary Jane to the theater because Curt Connors has imprisoned himself after turning back into the Lizard, so MJ is accompanied by Carlie. The star of the show Melanie Daniels is an old rival of MJ, who watching the show realizes how much she misses acting; when Electro stops the performance and takes Melanie hostage, in the end it is MJ and Carlie who save her. Kindred discovers that Mysterio has tricked his psychiatrist into believing he is him; Quentin, however, has taken an old alias and so the demon unmasks him, then giving him a script. Spidey manages to convince Dr. Connors not to run away from his fears but to face them, and as Peter agrees to join his class. MJ receives a call from her agent who tells her that thanks to Melanie's rescue, she has returned to fame and has found her a role in a movie. Mary Jane accepts the assignment, unaware that the producer / director is Mysterio. Meanwhile, Miguel O 'Hara seems to be in trouble ...
Appearing in "Team-Up"
Featured Characters:
Supporting Characters:
Antagonists
- Die-Chromator (First appearance)
- "Gremlins" (First appearance)
Other Characters:
- "Eugene" (Mentioned)
- D.D.F. (Mentioned)
- Tarzan (John Clayton Jr.) (Mentioned) (Topical reference)
- God (Yahweh) (Invoked)
Races and Species:
- Humans
- Unidentified alien species
- Gremlins (Mentioned) (Topical reference)
Locations:
- Earth
- United States of America
- New York
- New York City
- Manhattan
- East Village
- Bowery
- Peter, Randy, & Fred's apartment
- Bowery
- J. Jonah Jameson's apartment (Mentioned)
- Greenwich Village
- East Village
- Manhattan
- New York City
- New York
- United States of America
- Hell (Invoked)
Items:
- Spider-Man's Suit and Web-Shooters
- Scarpatio of Tears (First appearance)
- Cloak of Levitation and Eye of Agamotto
Synopsis for "Team-Up"
Coming home, Spider-Man finds J.Jonah.Jameson in his apartment, who insists on making him go to the alley under his house where strange lights and noises come from several nights. Entering the warehouse where they come from, the two find themselves faced with a strange being. After a brief confrontation, the being vanishes and Spidey decides to seek the help of Doctor Strange.
Appearing in "Robo-Helpers"
Featured Characters:
- Spider-Man (Peter Parker) (First appearance)
Supporting Characters:
- Kraven the Hunter (J. Jonah Jameson) (First appearance)
Antagonists
- Octopus Doctor (First appearance) (Apparent death)
Other Characters:
- Active-Radio Spider (First appearance)
- Ben Parker (First appearance; Peter Parker's imagination and photo)
- Death (First appearance; Peter Parker's imagination)
- Avengers (Mentioned)
- Mays Parker (First appearance)
- Stephen Hockey (Mentioned) (Topical reference)
- Daily Beagle (Named only)
- Spider-Ham (First appearance; photo)
- Betty Brant (First appearance)
- Silk (Cindy Moon) (First appearance)
- Gwen Stacy (First appearance)
- Mary Jane Watson (First appearance)
- Black Cat (Felicia Hardy) (First appearance)
- Kitty Pryde (First appearance)
- Harry Osborn (First appearance) (Cameo)
- Robbie Robertson (First appearance) (Cameo)
- Invisible Girl (Sue Storm) (First appearance) (Cameo)
Races and Species:
- Humans
- Abstract Entities (Peter Parker's imagination)
- Worms (Drawing)
- Spiders (Mentioned)
- Octopuses
- Pigeons
- Birds (Mentioned)
- Dogs (Drawing)
- Pig-Spider Hybrids (Photo)
- Mutants
- Lions (Corpse)
Locations:
- Earth-19925 (First appearance)
- Earth (First appearance)
- United States of America (First appearance)
- New York (First appearance)
- New York City (First appearance)
- Manhattan (First appearance)
- Financial District (First appearance)
- Upper New York Bay (First appearance)
- Statue of Liberty (First appearance)
- Queens (First appearance; Peter Parker's imagination)
- Ridgewood (First appearance; Peter Parker's imagination)
- Ridgewood Cemetery (First appearance; Peter Parker's imagination)
- Ridgewood (First appearance; Peter Parker's imagination)
- Manhattan (First appearance)
- New York City (First appearance)
- New York (First appearance)
- United States of America (First appearance)
- Earth (First appearance)
Items:
- Spider-Man's Suit and Web-Shooters (First appearance)
- Captain America's Shield (First appearance; illusion)
- Infinity Gauntlet (First appearance; illusion)
- Infinity Gems (First appearance; illusion)
- Reality Stone (First appearance; illusion)
- Mind Stone (First appearance; illusion)
- Space Stone (First appearance; illusion)
- Soul Stone (First appearance; illusion)
- Black Cat's Suit (First appearance)
- X-Uniform (First appearance)
- Kraven's Lion's Head Vest (First appearance)
- Fantastic Four Uniform (First appearance) (Cameo)
Synopsis for "Robo-Helpers"
What happens when a bot writes Spider-Man stories? It happens that our friendly neighborhood superhero has to face his worst enemy the Octopus Doctor, and that after defeating him while he is relaxing with quite a few beautiful girls, he is sent by his boss to take pictures of Spider-Man.
Solicit Synopsis
• Year two of Nick Spencer, Ryan Ottley and Humberto Ramos’ run on ASM begins here!
• In the giant-sized main story, Spider-Man and Mary Jane find themselves in an INCREDIBLY tough situation, thanks to Electro. Can Spidey save MJ? CAN MJ SAVE SPIDEY?
• What is Mysterio cooking, and what does it have to do with the bandaged villain who has been on the periphery since #1?!
• All this, plus a story by Dan Hipp (TEEN TITANS GO! Art Director), internet sensation Keaton Patti and MORE!
Notes
- When Doctor Strange says that being Spider-Man in his house is becoming a habit, he refers to the events of Friendly Neighborhood Spider-Man (Vol. 2) #5.
