Amy Chen survived a car accident that had killed her parents and left her with severe brain damage. Her condition was worsened when Doctor Octopus enacted his Global Warming scheme.
Amy became a H.E.A.R.T. Clinic patient, and Cardiac stole Otto's Neurolitic Scanner to help her. Upon learning of her condition and his involvement in it, Spider-Man (Otto Octavius/"Peter Parker") performs the operation himself. Afterwards, Amy thanks Spider-Man and gives him her doll, Mr. Pinky Penguin, and the Clinic gives her a Spider-Man Plushie.
Later, the goblins tied Amy to tunnel tracks and attempted to run her over. Spider-Man got her out of the way in time and consoled her. Then left her with a police woman. 
- 3 appearance(s) of Amy Chen (Earth-616)
- Mentions (or invocations) of Amy Chen (Earth-616)
- 2 image(s) of Amy Chen (Earth-616)