Billy Kitson was a champion basketball player who won a college scholarship and planned to become a professional basketball player, until another player accidentally tripped Billy which resulted in Billy getting a broken leg, ending his dreams and his relationship with his girlfriend Shimari Asbery. Billy Kitson had later made contact with the Egyptian god Seth, who turned Billy into the man-bull creature Bison to serve Seth in exchange for his leg being healed.
Seth sent Bison to capture a sample of the Inferno-42 weapon from S.H.I.E.L.D. This resulted in Shimari turning to Luke Cage and Thunderstrike to help Billy. Bison also ran afoul of Seth's other minions Quicksand and Mongoose whom, Bison later teamed up with to fight Luke Cage and Thunderstrike and but later turned on his partners. After saving agent Alex DePaul from his Mandroid Armor, Bison was let go.
Later on, Bison has joined the 7th incarnation of the Masters of Evil and was defeated in combat by the Thunderbolts. All Bison wanted was to get enough money for his own cure and to reunite with Shimari.
For a certain length of time, Bison was incarcerated in Prison 42 in the Negative Zone. After the prison was abandoned during the Skrull Invasion, Bison was among the inmates that were left behind and forced to defend the prison from Blastaar's forces.
Bison was one of many animal-themed superhumans captured by Taskmaster and Black Ant for Kraven the Hunter's Great Hunt. He appears as a member of Vulture's army. However, in the chaos, he died after being hit from several shots from the robotic hunters. 
The Bison possesses superhuman strength to an unknown degree, but roughly equivalent to that of Luke Cage. He can use his strength to perform a "Hulk-clap", creating a powerful blast of wind. The Bison has a durable hide, able to resist extreme injuries.
Superhuman, to an unknown degree
- Bison was one of the candidates on Steve Rogers' list of supervillains to enroll in Luke Cage's Thunderbolts roster.
- 10 Appearances of Billy Kitson (Earth-616)
- 1 Minor Appearances of Billy Kitson (Earth-616)
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- 1 Images featuring Billy Kitson (Earth-616)
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