Deuce was originally owned by Foggy Nelson, who intended to give him to Matt Murdock so that he could use Deuce as a guide dog. Matt declined, stating that he didn't want or need a guide dog.
Deuce became a favorite of Normie Osborn, whose mom Liz Allen was dating Foggy Nelson at the time. Deuce proved extremely valuable when a man entered the law office and shot at Nelson's mom Rosalind Sharpe. Deuce viciously attacked the shooter. Later, Deuce attacked another armed gunman who threatened Foggy.
Later, Foggy lost Deuce in a game of poker to Weasel, a co-worker of Deadpool. Since Weasel had no use for a trained guide dog, Deadpool suggested giving Deuce to his hostage, Blind Al. Blind Al hates the dog.