The history of this substance is largely shrouded in shadow, having been a confidential research experiment conducted by Norman Osborn. Norman accidentally created what would later become a virulent bioweapon while searching for a universal cure to genetic diseases to help cure his wife Emily of the genetic disease that eventually led to her death.

The substance, tagged GR-27 but nicknamed Devil's Breath by the lab technicians helming the research, was initially tested on a young Martin Li, and with disastrous consequences; the chemical gave Li volatile powers which led to the death of his parents when he accidentally killed them during the testing. The substance was later demonstrated to have even worse effects on the general public, where it acted as a viral agent. When infected by Devil's Breath, victims would exhibit progressively worsening symptoms, ranging from a bad cold or flu to hemorrhaging and ultimately, death.

The substance was locked away for a long time, but was later revealed to be the object of desire of a vengeful Martin Li, now operating under the moniker Mister Negative and using his powers to bring ruin to the city Norman had helped develop. Li obtained the substance when it was being transferred to a safe house, but it was later stolen back by Doctor Octopus and dispersed throughout the city, effectively destroying the only quantity of it but infecting several hundred thousand.

The substance ultimately led to the deaths of several New Yorkers, including Peter Parker's Aunt May. It was later destroyed completely when a cure was developed and replicated to stop the spread and cure the infected.


  • In Earth-616, Mister Negative used a weapon named Devil's Breath. However, it bears little resemblance to its other counterpart.

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