History
Dr. Frye was a medical doctor and expert in the field of radiation, working out of the small town of Turango, Colorado where he made a number of breakthroughs in chemo-therapy treatment for cancer patients. He married Claire Frye, and raised a son, Del. When Claire passed away, Dr. Frye was left with crippling existential fear and became obsessed with creating a medical breakthrough that could prevent death. He found himself drawn to the work of Bruce Banner, seeing him as the man that death could not claim and ignoring his colleague's beliefs that Banner's monstrous form was a cautionary tale.

Dr. Frye before his transformation
Frye began experimenting with Gamma Radiation, and injected himself with a serum that enhanced his physique without any visible side-effects. Encouraged by his immediate success, he pressured Del into taking the serum as well, claiming that with all the physical injuries sustained in football, his star athlete son would need the serum to protect him when he went professional. Unlike his father, Del suffered side effects of the injection immediately, his eyes turned a deep green, and green blood began pouring from his mouth and eyes as he hallucinated about a Green Door and a being beyond it, before he collapsed dead.
Horrified and ashamed that he had killed his own son, Dr. Frye rushed his burial at the Green Peak Cemetery, before burning the formula and all his notes so no one could replicate his work. Shutting himself inside his home and refusing to speak to his neighbors out of guilt, no one noticed when Dr. Frye began to experience the delayed side-effects of the serum for himself, his skin became irradiated and glowed a sickly green, and his hair fell away, leaving him with the appearance of a desiccated, glowing skeleton. Frye went into exile deep in the caves of the local mountain, where he killed anyone who stumbled upon him, draining the life from them with a touch.
What Frye didn't realize was that since he didn't reveal Del's cause of death, his son was given a regular burial, and the distance between the casket and the ground was too shallow to contain the radiation emanating from the body. As mourners visited the cemetery, they were infected with Gamma sickness, and died as well, spreading a phenomenon the locals dubbed a "Chain of Grief." Bruce Banner visited Turango while drifting across the country, and learned of this regional illness. He visited Del's grave and identified the Gamma radiation coming from it. After alerting the E.P.A., Banner scaled the mountain where Frye lived, since he had noticed a flash of green coming from it hours earlier.

Left dismembered by the Hulk
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Notes
- In the original script for Immortal Hulk #2, Dr. Frye was called Hendricks.[2]
See Also
- 1 appearance(s) of Doctor Frye (Earth-616)
- 1 minor appearance(s) of Doctor Frye (Earth-616)
- 2 mention(s) of Doctor Frye (Earth-616)
- 12 image(s) of Doctor Frye (Earth-616)