Not much is known about the past of Doc Locke. At some point in his life he became a medical expert and was recruited by Singularity Investigations. After one of Multiple Mans dupes destroyed Singularity Investigations, Doc Locked joined Hydra.
Soon after, Ms. Diaz kidnapped Madrox Prime, believing he was his dupe who was working for S.H.I.E.L.D., Doc Locke tortured him mentally. He discovered that Multiple Man's powers are not just celluar duplications.
Doc Locke was most likely killed in a crushing crowd after Madrox created more and more dupes after slapping his own face for a few times.
- His fate is unknown. It is possible that he died because the duplicates of Multiple Man crushed him. 
- 1 Appearances of Doctor Locke (Earth-616)
- Minor Appearances of Doctor Locke (Earth-616)
- Media Doctor Locke (Earth-616) was Mentioned in
- 1 Images featuring Doctor Locke (Earth-616)
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- Character Gallery: Doctor Locke (Earth-616)
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