Scream was a member of the Sinister Syndicate. When the members of J. Jonah Jameson's "Team Scoop" stumbled upon their lair, Scream stared at them, pointing them out when Electro heard them. After Electro failed to destroy them, Scream attempted to pounce on them. Doc Ock, however, held her back, claiming "Get away, they're mine!", as she helplessly attempted to claw at them. She hissed at them while they made their escape.
She was once more seen using her hair to tie Spider-Man to a pole, attempting to keep him from protecting Team Scoop. Spidey managed to escape and defeat her. She was later seen, along with the rest of the Syndicate, webbed up and captured.
- 1 Appearances of Donna Diego (Earth-TRN160)
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- 3 Images featuring Donna Diego (Earth-TRN160)
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