In this reality, Thanos joined the Avengers in the war against the Builders. He lead a strike-force on to the main Builder command ship where Thanos' true motives were brought to light. He wanted to kill his son Thane for joining their enemy and as a tribute.

This caught the attention of Captain America who fought Thanos and was later killed by him while also clinching the battle in the Earth's favor. Thanos ended up taking over Rogers place as leader of the Avengers and his place among the Illuminati who were dealing with the Incursions.[1]

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