Aunt May forced Spider-Man to wrap up warmly for winter. 
She gave Kraven the Hunter, Green Goblin and Mysterio before beating them unconscious with a frying pan. 
She found one of Spider-Man's suits and turned it into a tablecloth and curtains.
She discovered Spider-Man fighting Rhino and called animal control and pest control on them.
While Spider-Man was fighting several villains she called time and had them all come to her house to knit together.
When Peter was about to tell her his secret identity, Aunt May saw a spider and killed it so aggressively it stopped Peter from revealing it. 
Aunt May stopped a fight between Spider-Man and Doctor Octopus in order to wrap each of them in more protective clothing. 
One evening she discovered Green Goblin and Hobgoblin stealing her pumpkins and chased them off with a broom. 
She was about to be attacked by Venom and Sandman while cleaning the house and used the vacuum to suck up Sandman and the symbioate. 
Spider-Man had the Avengers over, while the city was burning and Aunt May insisted they stay for tea.
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