She was asked by her co-anchor Jason to the school's homecoming dance, but she rejected him on air.
Betty was disintegrated by Thanos alongside half of the universe , and resurrected five years later by Bruce Banner.. Much to her annoyance, as from her perspective she and her classmates had just finished midterms before being snapped, Midtown High had to restart its school year to accommodate the resurrected.
Towards the end of the school year, Betty joined her classmates on a field trip to Europe. She started a relationship with Ned Leeds while on the trip, but the trip suffered complications due to the presence of monsters known as the Elementals. In Prague, Ned and Betty were attacked by the Fire Elemental, but Spider-Man, under the guise of what Ned claimed was a "European rip-off" named Night Monkey, teamed up with Quentin Beck and seemingly defeated it. However, Beck turned out to be a fraud and staging the Elementals' attacks. Due to Spider-Man accidentally telling Beck about who knew his secret, Beck targeted Ned, Betty, and MJ to kill them. Betty joined up with Happy Hogan to hide, but Spider-Man ultimately defeated Beck. Afterwards, Ned and Betty broke up, but remained friends.
- Angourie Rice portrays Betty Brant in the films Spider-Man: Homecoming and Spider-Man: Far From Home.