Little is detailed about Apocalypse's life before Bishop arrived from the future to prevent the release of the plague. However, it can be presumed that it followed as much of the same path as his Earth-92131 counterpart.
Apocalypse masqueraded as a member of the Friends of Humanity and used Graydon Creed in creating a virus to infect and kill every mutant on Earth. When Apocalypse revealed himself and his plans to Creed, the X-Men and Bishop ambushed them. They successfully destroyed the plague, but were then killed by Apocalypse.
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