The past history of Apocalypse of Earth-21993 mirrors that of his Earth-616 counterpart up until the point where Charles Xavier was going to be used as a weapon by the Skrulls to attack the Shi'ar empire. Xavier would escape this fate and return to Earth where he would be assassinated by Cable, sparking an explosion of attacks instigated by many of the X-Men's enemies.
With the death of Xavier, Apocalypse would be one of the many X-Men foes to capitalize on the chaos caused by Xavier's death. He and his Dark Riders would target the Scarlet Witch for reasons that remain unrevealed. He would be opposed by the Avengers, the outcome of their battle would remain unrevealed. His current activities are unknown.