- In an interview with Entertainment Weekly about the episode "Self Control" of Marvel's Agents of S.H.I.E.L.D., showrunners Maurissa Tancharoen and Jed Whedon describe the Framework as an alternate reality.
- Similar to Earth-85826 and Earth-616 during Secret Empire, the Framework is a reality ruled by Hydra.
- The virtual reality within the Framework features several key points of divergence from the real world. These resulted from its users' biggest regrets and desires:
- Jeffrey Mace was born an Inhuman.
- Phil Coulson turned down an offer to join S.H.I.E.L.D..
- Alphonso Mackenzie's daugther Hope wasn't born with the unstable medical condition that killed her, allowing Mack to raise her as a loving father.
- Melinda May managed to save Katya Belyakov in Bahrain.
- Leo Fitz grew up with his father Alistair instead of his mother. He also met and fell in love with Ophelia at the S.H.I.E.L.D. Academy, instead of meeting and befriending Jemma Simmons.
- Grant Ward was recruited to join S.H.I.E.L.D. by Victoria Hand when he was in a juvenile detention centre, instead of being recruited to join Hydra by John Garrett.
- Given the way that alternate realities are usually created it can be presumed there are a number of realities parallel to this one all stemming from each new addition to the Framework; one being the reality diverging from May never killing Katya but where Coulson still joined S.H.I.E.L.D. etc. The only difference not informed by the desires of a person from Earth-199999 is the recruitment of Grant Ward to S.H.I.E.L.D. rather than the Hydra conspiracy within it.
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