According to the griot spirits of the Djalia, the Orisha originated during immemorial times in the land that would become Wakanda. When the pilgrims who traveled to this land entered in conflict with the native beasts that lived on it, the Originators, the heroes that rose among the humans were ascended to gods on faith. These gods, the Orisha, were Thoth, Kokou, Mujaji, Ptah, Nyami and Bast. The humans and the Orisha defeated the originators and banished them to the Nether-Realms beyond a group of gates. As part of their duty, the Orisha became guardians of these gates.
In Kinamasi, a faction of protesters abandoned their worship to the Orishas and preached the coming of a new god, Sefako. Counselor Yao of Kinamasi was certain that a schism was brewing. Others in Wakanda, such as in the Alkama Fields chose, on her return, to worship Hadari Yao (the "Walker of Clouds" in the old Alkamite tongue), the Goddess who preserves the balance of all natural things: Storm, for her to defeat the Anansi, man-spiders of myth and legend. Once the Anansi were repelled, Ororo used the belief in her from the Alkamites to once again inspire confidence in their king and country, ultimately ascending to godhood herself.
- Both Black Panther (Vol. 6) #13 and #15 depict the Orishas of Wakanda as a group of five including Thoth, Bast, Kokou, Mujaji and Ptah. Yet, in #15, T'Challa mentions Nyami, who could be Nyame, another name of Vodū Sky Father Buluku.
- The previously introduced Orishas are part of the Ennead (Bast and Ptah) and related gods (Thoth), forming the Gods of Egypt, and not of the "classical" Orishas of Africa, the Vodū.
- Others first appeared as Gods of Wakanda, and haven't been confirmed as any known groups, though they are inspired by beings from our reality's African mythologies, such as:
- In addition to the main pantheon, other gods from Egypt are worshiped in Wakanda like the Sekhmet (as Lion God)  and Sobek (Crocodile Cult) the gorilla gods worshiped by the Jabari tribe come from elsewhere in Africa: Before being Jabari, they worshiped Ngi from Yaoundé people (Cameroon). Currently, the tribe is known to worship Ghekre from Baoulé people (Ghana and Ivory Coast).
- 6 appearance(s) of Gods of Wakanda (Earth-616)
- 2 minor appearance(s) of Gods of Wakanda (Earth-616)
- 19 mentions of Gods of Wakanda (Earth-616)
- 1 image(s) of Gods of Wakanda (Earth-616)
- 8 member(s) of Gods of Wakanda (Earth-616)