A group of heroes who opposed the Phalanx conquest of the Kree system (and many who had opposed Annihilus incursion into their universe), who banded together in an attempt to prevent any further catastrophes from ever occurring.
On the recommendation of ally Nova, the group establishes a base of operations at the space station Knowhere, which possesses a teleportation system with near-universal range. An intelligent, super-powered dog called Cosmo acts as Knowhere's chief of security and works closely with the new team.
After an initial clash with the revitalized Universal Church of Truth, the team's investigation of a mass of "Limbo ice" reveals a semi-amnesiac man who identifies himself as Vance Astrovik, Aka Major Victory of the Guardians of the Galaxy of Earth-691. Astro's declaration inspires the as-yet-unnamed team to adopt the "Guardians of the Galaxy" name for their own.
The team then battles the Universal Church of Truth once again, while Astro is attacked aboard Knowhere by an incarnation of his former teammate Starhawk. Matters worsen when the alien shape-shifting Skrulls apparently infiltrate Knowhere, and the revelation that Star-Lord directed Mantis to telepathically coerce the heroes into joining the team.