"Guest House" was a former top-secret storage facility at a classified location, previously affiliated with the Strategic Scientific Reserve and S.H.I.E.L.D.

It is a heavily fortified facility located inside a mountain approximately 17 miles northweast of an undisclosed North America location.

It was used as a munition bunker during World War II, and later upgraded by the SSR for a classified use.

This facility was never formally decommissioned, although it was damaged by seismic activity in the mid 1950's.

Since then, it remained officially unaffiliated with the SSR or S.H.I.E.L.D.

Following the Battle of New York, Fury reopens the Guest House, which is used to resurrect Agent Phil Coulson. Numerous operations and doctors were brought in, using unknown and unethical procedures to bring back the deceased S.H.I.E.L.D. agent. Upon regaining conscious though, Coulson begged to die, so the doctors were ordered to rewrite his memories so that Coulson would believe that he recuperated in Tahiti.

About a year later, Coulson managed to locate the Guest House, hoping to find a treatment or drug to save the life of his team member Skye. The two guards stationed at the facility demanded an answer to the countersign, "How was the drive from Istanbul", to which no one could answer, forcing Coulson and his team to kill them in self-defense. Unfortunately, without the guards, no one could stop the impending self-destruct sequence. Coulson was then able to find a sample of the GH-325 used to heal his wounds, but then spotted a door marked T.A.H.I.T.I. Inside, he finds numerous versions of the GH drug and the source of it, a corpse of a blue-skinned alien, from which the drug is milked. Coulson and his team then escaped the Guest House shortly before it is destroyed. Little did they know that they led the "Clairvoyant", Hydra agent and Project Centipede leader, John Garrett, to the facility, having infiltrated the place under the guise of helping Coulson, having managed to steal multiple vials of the GH drug as he could.

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