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History

Quote1 And isn't it also true that whenever you punch a ninja you say "Talk to The Hand" and laugh maniacally at your own lame joke? Quote2
--Deadpool[src]

The Hand seemingly had a similar history as its Earth-616 counterpart.

They was among the super-villains who were involved in brainwashing Deadpool. When Wade was freed of his programing, he targeted those involved in his brainwashing, including The Hand.[1]

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