Henry Gyrich shared a similar history to his Prime Universe counterpart until Iron Man was infected and ultimately succumbed to the Extremis virus before the Civil War. After the Stamford incident the government passed the "Super-Hero Registration Act", and Gyrich the leader of the government division that opposed Captain America and his group. Initially he unleashed Sentinels but these were not trusted to be able to arrest without killing. He next unveiled Sentinel O*N*E Strikeforce which were able to drive the heroes underground but were proven to be less effective against villains who did not have the same moral code. He finally unleashed Thor clones which were able to bring about the deaths of several heroes. When Jim Rhodes tried to negotiate a peace, Gyrich found out and murdered both him and Cap. Gyrich was able to spin this to be able eventually become President of the United States.