During Earth-TRN461's Venom initiation battle into the Resistance, the fight was brought to his reality. They allied with Thanos in exchange for him sparing their species if he managed to destroyed half the universe. They were sent to obtain the Mind Stone from Iron Man, but were defeated by the combined forces of the Avengers, Resistance, and Spider-Men.
Stuck on Earth-TRN461, the poisons needed a new homeworld. They chose Klynatr, sending Poison Rhino and Poison Spider-Man to uproot their government. They locked up most of the Klyntar in the Symbiote Prison. Riot had evaded capture and was able to free its brethren, starting the Poison/Symbiote War. In the end, they agreed to a truce, giving the Poisons their own territory.
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