- Ego the Living Planet (First appearance)
- J Jonah Jameson (Appears on a computer screen, TV, or hologram only)
- Spider-Man (Peter Parker) (Mentioned)
- United States of America
Ego the Living Planet arrives near Earth causing Hulk and the Agents of S.M.A.S.H. to investigate. After an attack on Ego rom their spaceship, S.M.A.S.H. are surprised that Planet has sentience as their ship gets caught in his gravity and causes it to crash. Ego reveals that he has absorbed planets to grow in size. Hulk and the team then start to pummel the living planet. Red Hulk suggest that they go into Ego's body to take out his brain as they fall into living planet's mouth. S.M.A.S.H. then work to break their way through Ego's teeth as Red Hulk blasts a hole through one of living planet's teeth and gets out. After getting out of Ego's mouth, the Agents of S.M.A.S.H. fight their way past the appearance of acid-spewing zits as they make it to Ego's nose as Red Hulk is sucked into Ego's nose. Red Hulk's approach towards Earth causes gravity quakes on Earth. When Red Hulk fires in Ego's nose, it ends up sneezing out Red Hulk as Hulk is knocked off of Ego. Ego states to the Agents of S.M.A.S.H. that Earth will soon be extinguished by him. With help from a shuttle piloted by S.H.I.E.L.D. astronauts, Hulk gets back on Ego as the Agents of S.M.A.S.H. free Red Hulk from Ego's mucus. Hulk then has his team mates rip out Ego the Living Planet's nose hairs causing him to sneeze. This time, the Agents of S.M.A.S.H. grab on to one of Ego the Living Planet's nose hairs as they proceed to Ego the Living Planet's brain. After Hulk landed an attack on Ego's brain, the Agents of S.M.A.S.H. find Ego's ego section as he tries to get Red Hulk to rule with him. Red Hulk doesn't fall for it as Hulk tells Ego that he can either leaves their galaxy or they can "slam dunk him into the sun." Ego submits and leaves the galaxy.