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Still reeling from Electro's death, Yu Komori became involved when a large lizard-like creature attacked the medical research company owned by the father of his best friend, Araki. Consulting Dr. Inumaru, a biologist friend and mentor of Yu's, Yu and Araki noticed blood on the doctor's lab floor. Shortly after that, the pair were are attacked by the Lizard, and Araki was abducted.

Araki's father receives a ransom demand from the Lizard to deliver the notes on a new formula being developed, and Spider-Man promised to rescue Araki. As Araki's father made the ransom drop, Spider-Man watched from a distance and saw Dr. Inumaru, realizing that his mentor was the Lizard. Dr. Inumaru destroyed the formula notes and revealed that a year prior, Araki's father had tried to murder Inumaru over a new medical discovery. Surviving the attempt on his life, but abandoned in the harsh jungle, Inumaru fought to survive, until he somehow contracted a form of therianthropy, and learned that he could now assume a lizard's form when he was angry. Spider-Man saved Araki from Inumaru's crocodiles, and ordered Araki and his father to flee. When Yu was unable to reason with the Lizard, even going so far as to tell the Lizard Spider-Man's true name, he was forced to kill the Lizard by throwing him to the crocodiles. At the last second, however, the Lizard reverted to Inumaru, suggesting that in his last moments, he found some peace.[2]

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