Jesse Drew was born on the Moon to S.H.I.E.L.D. agents Jonathan and Miriam Drew. He followed in his parents' footsteps, joined S.H.I.E.L.D. right after high school, and was eventually sent to renovate the very moonbase he was born in. Jesse and his team got attacked by venomous space spider parasites and only Jesse managed to escape back to Earth. The infection threatened to kill him, but his life was saved by Cindy Moon, who developed an isotope that allegedly stabilized Jesse's condition and granted him Spider-like powers; however, Cindy had lied to Jesse and convinced him that he required regular injections of her isotope in order to survive. Both of them splintered off from S.H.I.E.L.D. and formed S.I.L.K., an international crime organization in which Jesse acted as Cindy's right hand man under the codename Agent 77.
- Superhuman Strength: Isotope enhancements make Jesse much more stronger compared to an average Human.
- Superhuman Agility: Jesse is fast and nimble enough to go toe-to-toe with his alternate counterpart.
- Wall-Crawling: Although he is not a Spider-Totem, Jesse is able to stick to and crawl on walls and ceilings.
- Jesse's abilities are not permanent, he requires regular intakes of Radioactive Spider Isotopes to maintain them. He also goes through a mild withdrawal if the interval is extended.
- 6 Appearances of Jesse Drew (Earth-65)
- 3 Minor Appearances of Jesse Drew (Earth-65)
- Media Jesse Drew (Earth-65) was Mentioned in
- 9 Images featuring Jesse Drew (Earth-65)
- 1 Quotations by or about Jesse Drew (Earth-65)
- Character Gallery: Jesse Drew (Earth-65)
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