One of the high-ranking Nazi’s during the Second World War, The Red Skull tried to force a young John Hardesky into revealing the Super-Soldier formula. The Red Skull was constantly battling the Allies' greatest champion, Captain America, who was created by the formula. After learning that one of their scientists had been kidnapped, the Allies sent Wolverine and Captain America to rescue him. After realizing that they had been set up and the scientist was there willingly, they were captured by The Red Skull.
After escaping, they came face to face with The Skull and defeated his Sleeper robot before The Skull escaped on his plane. Captain America and the Six American Warriors confronted the Red Skull once again when the Skull attempted to build a Doomsday Weapon. However, in a fight, Cap and Skull were trapped in a vortex, and remained unreleased for fifty years.
Fifty years later, the Red Skull's son, Rheinholt Kragov, and step-son, the Chameleon, released him from the vortex. It was then that the Red Skull unveiled the Doomsday Weapon, which he used to turn his son into Electro. However, Electro betrayed his family, but was defeated by Captain America and Spider-Man. After another fight, Red Skull and Captain America were trapped in the vortex once again.
Red Skull was later forced to take part in a contest between good and evil set up by the Beyonder on an alien world. Skull, Doctor Doom, the Lizard, Doctor Octopus, and Alistaire Smythe were allowed to run amuck on the alien world for a year before Spider-Man and other heroes were allowed to face them. Skull, Doctor Doom, and Doctor Octopus were eventually defeated while the Lizard and Smythe joined the heroes so they could leave the planet. The Beyonder then reversed everything that the villains had done and returned them and the heroes except Spider-Man to Earth with no memory of the event; Skull presumably was returned to the vortex along with Captain America.