Karen Lee was the wife of Thaddeus Ross's commanding officer. After the two married, Karen followed him to every post he was assigned, until the birth of their daughter, Betty, after which Ross pulled every string he could to get him assigned to a base close to his childhood home in New Hampshire, so the two could raise Betty there. Twelve years after Betty's birth, Karen died of cancer.

The memory of Karen was used by Zero/One when she sough to analyze Ross' (as Red Hulk) memories for reasons to preserve humanity. Skipping from their marriage to her death, Ross lamented on all the good she skipped over between those moments.[1]

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Karen Lee

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