An ancient cosmic entity predating the universe itself, Knull reigned over the primordial Void and was enraged when the Celestials began filling the nascent universe with Light, declaring war on them. Using the living abyss of his own shadow, Knull forged the first four Symbiotes - All-Black, Scream, Mania, and Scorn - and used them as weapons.
When most of the Celestials had been slain, Knull considered his task complete and attempted to forsake his creations - no longer having any use for them. When the four symbiotes refused to separate from him, Knull was enraged and tore them from his body, leaving them for dead and returning to the Void from whence he had come.
Vicious, cruel, warlike, and controlling, Knull was furious when the Celestials began spreading light throughout the primordial universe and created the symbiotes to serve as weapons in his war against them. Once most of the Celestials were killed, Knull callously discarded the symbiotes - who he had viewed as mere tools despite them being living creatures - and left them for dead when he felt he had no more use for them.
- The Exolon also existed in this universe, but it is unknown if Knull created them like in Earth-616.