X-23 is an adult, and a prominent member of the X-Men and the XSE (X-Treme Sanctions Executive) X-23, M, and Iceman are sent to Hong Kong to locate and capture the renegade XSE member, Sage. However, Sage uses her considerable espionage skills to ambush X-23, attaching a mysterious collar to her neck that temporarily overwhelms X-23. Sage removes the collar and attempts to flee just as Iceman arrives and freezes her in ice, allowing the group to safely take her into custody.
X-23, Marvel Girl, M, and Wolverine are sent by Cyclops to locate the whereabouts of Mister Sinister, Gambit, and the missing Summers and LeBeau children. The group finds Sinister's hidden base but are immediately immobilized by an attack from the Ladies Mastermind. It is shown that she is in love with Fantomex, and it is revealed during an illusion caused by the Ladies Mastermind that her dream is for them to be married as a normal suburban couple with a daughter.
The team members live out fantasy existences until Wolverine breaks them free of the mind control. Charging deeper into the base, the group fights against Sinister's Marauders to save the children. Later, X-23 and the X-Men travel to Shi'ar space, and a massive battle ensues. She is one of the very few X-Men who survive and is seen attending to Kitty Pryde's speech at the end of the conflict.
Laura later appeared as Professor Kinney, who is responsible for training the next generation of X-Men. She is shown to be capable of overpowering them despite her size and the fact that there is only one of her. She appears relatively youthful, indicating that her aging has been slowed by her healing factor.