Lydia Nance grew up in a poor household in Long Island, and was physically abused by her mutant father. As a an adult, Nance became the director of the Heritage Initiative, an anti-mutant organization. She was interviewed on television by the Fact Channel, where she expressed her views of mutants as beings of mass destruction and dismissed the prejudice they suffered.
In an attempt to further damage the reputation of mutantkind, Nance paid the mutant hypnotist Mesmero to assemble a new incarnation of the Brotherhood of Evil Mutants and commit terrorist acts. Firstly, the Brotherhood attacked the United Nations Headquarters, and then kidnapped the mayor of New York and held him hostage. The latter mission was intended to lure the X-Men to a trap to kill them in an explosion. Not only did the Nance's plan fail, but also when the X-Men were fighting the Brotherhood, Prestige discovered about Mesmero's involvement with Nance. The X-Men confronted Nance, and intimidated her in light of being unable to properly accuse her due to having no admissible proof.
After working with Mesmero on a plan to incarcerate the X-Men by making them attack police officers under the belief they were villains, Nance was approached by the advanced Sentinel Alpha with a plan to destroy mutantkind. She provided him with a Heritage Initiative facility in the Savage Land, where Alpha developed a lethal smart virus capable of targeting mutants derived from the remnants of the Legacy Virus in the body of Colossus, whom Alpha kidnapped to this end. The X-Men tracked down Colossus to the Savage Land base, and Nance was knocked out cold by Kitty Pryde. She was later held at the Triskelion on the charge of attempted genocide since her and Alpha's plan was eventually thwarted.
- 13 appearance(s) of Lydia Nance (Earth-616)
- 1 minor appearance(s) of Lydia Nance (Earth-616)
- 4 image(s) of Lydia Nance (Earth-616)