The Six would be sent to bring in the Warriors of the Great Web from the Brooklyn Navy Yard. While them initially provoked a fight, they successfully brought them back to Ozcorp Tower. There, Scorpion was present to see the heroes agree to help Osborn learn of the Web of Life and Destiny.
Shortly afterwards, Osborn received a message from the believed deceased Peter Parker. Going into a frenzy, he assembled the Six to end Parker.
Capturing Parker, they returned to Ozcorp Tower to find that the Spiders caused a feedback loop on a machine connected to the Great Web. Norman took the advantage of all of the spiders being unconscious in the same place to tap into the chair's power, but Peter sabotaged the machine, giving Osborn brain damage. The Sinister Six appeared immediately after the spiders had recovered, ready to destroy them now that Osborn was out of the picture. Spider-Man (Pavitr Parbhakar) threatened the Sinister Six with using the chair to boost their powers, and the villains called his bluff, prompting them to surrender.
- 4 Appearances of MacDonald Gargan (Earth-22191)
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- 9 Images featuring MacDonald Gargan (Earth-22191)
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