- Major plot events:
- Founding of Graymalkin Industries
- Formation of the X-Club
- Emergence of Hellfire Cult and Sisterhood of Mutants as antagonists to the X-Men
- Introduction of Proposition X
- Skrull invasion of the Earth is hindered on the west coast because of the unexpected migration of the remaining mutant community to San Francisco
- Anole and Graymalkin bonding over their sexuality while Beast explores Graymalkin's history.
- Juggernaut struggles between a life of crime or a life as a hero.
- Forge create mutants and start a war with an other kind of mutants from an alternate dimension, travelling with devices called Ghost boxes.
- This event is proceeded by Divided We Stand; runs concurrent with Secret Invasion, X-Infernus, Dark Reign; and followed by Utopia.
- About half of the stories in Manifest Destiny refer in some way or another to Kitty Pryde's disappearance.
- Media "Manifest Destiny" was Mentioned in
- Images showing "Manifest Destiny"
- Event Gallery: Manifest Destiny