- Inhuman Royal Family
- Inferno (Dante Pertuz) (First appearance)
When townspeople are transformed into primitive creatures, the Avengers attempt to help them by putting themselves into conflict with the Inhumans.
- Hulk shows knowledge about Inhumans from meeting them before in his Hulk and the Agents of S.M.A.S.H. animated series.
- Ultron wears a red cloak referencing his Earth-616 counterpart's Crimson Cowl disguise.