Are you guys seriously a video about this? Everything you need to know is in the story title: Deadpool Kills the Marvel Universe! It doesn't get anymore TR;DR than that. 
Appearances
Featured Characters:
- Deadpool (Wade Wilson) (Only in recap)
Supporting Characters:
Antagonists:
- X-Men (Earth-12101)
- Charles Xavier (Earth-12101)
- Wolverine (Logan) (Only in recap)
- Psycho-Man (Earth-12101)
- Avengers (Earth-12101)
- Aunt May (Only in recap)
- Trish Tilby (Only in recap)
- Mary Jane Watson (Only in recap)
- Anthony Masters (Earth-12101)
- Francis Castle (Earth-12101)
Other Characters:
- Noah Sterling (Death)
- Deadpool (Wade Wilson) (Earth-616) (Only in recap)
- X-Men (Earth-12101)
- Karl Mordo (Earth-12610)
- Quentin Beck (Earth-12610)
- Todd Arliss (Earth-12610)
- Norman Osborn (Earth-12610)
- Fantastic Four (Earth-12101)
- Uatu (Earth-12101)
- Peter Parker (Earth-12101)
- Johnathon Blaze (Earth-12101)
- Howard Duckson (Earth-12101)
- Victor von Doom (Earth-12101)
- Bruce Banner (Earth-12101)
- Puppet Master (Phillip Masters) (Mentioned)
- Lilith (Earth-12101)
- Curtis Connors (Earth-12101)
- Matthew Murdock (Earth-12101)
- Natalia Romanova (Earth-12101)
- Thanos (Earth-12101)
- Norrin Radd (Earth-12101)
- Comic Book Creator (Only in recap)
- Mistress Death (Mentioned)
Species
- Mutants (Only in recap)
- Traanian (Only in recap)
- Humans (Only in recap)
- Duckworldians
- Titans (Eternals)
- Zenn-Lavians
Locations:
- Multiverse (Only in recap)
- Earth-616 (Mentioned)
- Earth (Mentioned)
- Earth-12101 (Only in recap)
- Earth (Only in recap)
- United States of America (Only in recap)
- New York (Only in recap)
- New York City (Only in recap)
- Manhattan (Only in recap)
- New York City (Only in recap)
- Florida (Only in recap)
- Everglades (Only in recap)
- Man-Thing's Swamp (Only in recap)
- Nexus of All Realities (Only in recap)
- Man-Thing's Swamp (Only in recap)
- Everglades (Only in recap)
- New York (Only in recap)
- United States of America (Only in recap)
- Microverse (Mentioned)
- Earth (Only in recap)
- Earth-12610
- Earth-41210 (Only in recap)
- Unknown Reality (Deadpool Kills Noah Sterling)
- Earth-616 (Mentioned)
Items:
- Deadpool's Suit (Only in recap)
- Cyclops' Visor (Only in recap)
- Wolverine's Suit (Only in recap)
- Fantastic Four Uniforms (Only in recap)
- Spider-Man's Suit (Only in recap)
- Doctor Doom's Armor (Only in recap)
- Mjolnir (Only in recap)
- Pym Particles (Only in recap)
- Deadpool's Katanas (Only in recap)
- Carbonadium Katana (Only in recap)
- Psychic Clay Puppets (Only in recap)
- Daredevil's Suit (Only in recap)
- Black Widow's Gauntlets (Only in recap)
Vehicles:
Synopsis
Today, Marvel tells the unbelievable story of Deadpool Kills the Marvel Universe. This, friends, is the tale of a single man taking on an entire universe. Follow Deadpool as he goes on a journey of self-awareness, laughter, and mayhem!