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Quote1 I couldn't help but feel responsible for Mary Alice. Even though I hadn't seen her in years, the poor woman couldn't escape the curse of knowing me. Quote2
-- Spider-Man (Otto Octavius/"Peter Parker") src
 

Mary Alice Anders was introduced to a co-worker of hers, Otto Octavius. She knew him by reputation and was impressed by his mechanical arms that he had invented to handle dangerous chemicals.

They became closer and their relationship became deeper until eventually, she agreed to marry him. Overjoyed, Otto told his mother, who responded by being very angered that her son would abandon her like that after she raised him. His mother influenced Otto to break off his engagement, breaking both his own, and Mary Alice's hearts. Mary Alice would later die from an HIV infection, despite Doc Ock's attempts to synthesize a cure.[2]

It was later revealed that Norman Osborn was the one who was responsible for infecting Mary with HIV. He had her run off the road, and then infected her with a blood transfusion, in an attempt to desensitize Doc Ock.[3]




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