At a field trip to Osborn Industries, Peter is bitten by a spider, which grants him powers. It is later revealed that Norman Osborn had injected a super drug known as OZ into the spider, which he later uses as a sports drink which he sells to Mary Jane's classmates.

As Peter suits up to become Spider-Man, Mary Jane sets out to expose Norman with the help of Peter.[1]

Romance novelist Judith O'Brien wrote two novels featuring a teenage Mary-Jane. It featured illustrations by Mike Mayhew. It doesn't fit into any of the comics' continuity, although it claims to be 'inspired' by Ultimate Spider-Man.

The first novel is a basic retelling of the origin story from Mary-Jane's point of view. She is depicted as a shy, insecure girl who knew Peter Parker from elementary school. She deals with such teen topics like anorexia and peer pressure.

The novel was successful with teenage girls who weren't familiar with the comics, but was met with criticism from the core fans due to what they considered mischaracterization of some of the characters (most notably Harry Osborn, who is portrayed as somewhat of a punk who manipulates Peter into doing his homework while treating him horribly) and its fooling around with continuity.

A sequel, Mary Jane 2 was later published. This one dealt with the continuing relationship of Peter and Mary Jane, and the emergence of new girl Gwen Stacy. In this continuity, Gwen is an 'ugly duckling' who Mary-Jane gives a 'makeover'. However, Gwen soon has feelings for Pete.

Harry Osborn reappears and is made more sympathetic than he was in the previous novel; with his father in jail, he is now poor and has to live without a life of luxury.

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