Due to her nephew Peter having forgotten his lunch at home, May Parker rushed to a science demonstration to give it to him. There she was bitten by a Radioactive Spider which gave her spider-like powers.
Using a costume to hide her real identity, May set out to earn money for the family doing stunts. However, when the villain Leap-Frog made an appearance, the Spider-Ma'am defeated him and became a crime fighter.
During the Great Hunt, Karn came to Earth-3123 to kill the spider-totem of this reality. May surrendered herself willingly, if only to keep her husband and nephew from harm. However, Karn was stopped by the Spider-Army.
After revealing her identity to her family, they were supportive of her superhero career and created Team Spider-Ma'am. They ran reconnaissance and Peter also created and maintained Web-Shooters for her.
Spider-Ma'am was recruited into the Spider-Army to battle the Inheritors on the Prime Marvel Universe. The geneticists of the Superior Spider-Army ended the threat of the Inheritors by transferring their consciousnesses into infant human baby bodies. The children were adopted by May, taking them back to Earth-3123.
- 5 Appearances of May Reilly (Earth-3123)
- 2 Minor Appearances of May Reilly (Earth-3123)
- Media May Reilly (Earth-3123) was Mentioned in
- 13 Images featuring May Reilly (Earth-3123)
- 1 Quotations by or about May Reilly (Earth-3123)
- Character Gallery: May Reilly (Earth-3123)
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