When Melissa had her Bat Mitzvah it did not have a reception, with the family instead breaking into their neighbours house to celebrate it.
Melissa had a boyfriend who was accidentally killed by an A.I.M. Agent.
During her first weekend with M.O.D.O.K. since him moving out, Lou and Melissa were taken to a GRUMBL leadership conference. Melissa was able to use her social skills to help M.O.D.O.K. climb GRUMBL's social ladder. Growing impatient, however, M.O.D.O.K. opened a portal to Broodworld as a ploy to become more popular, causing a group of Ciegrimites to emerge and party. This upset Melissa and caused her to leave, going to the hotel spa. After M.O.D.O.K. killed the Ciegrimites and their business trip was over, M.O.D.O.K. was able to partially reconcile with Melissa, though Melissa didn't need to visit him anymore as a result of their arrangement.
Due to an upcoming book signing with Jodie's new boyfriend, Wonder Man, Melissa gave M.O.D.O.K. a makeover at his request. Melissa later played the paino at the book signing to meet Jodie's expectations of the children she described. Getting sick of being used by their mother, Melissa and Lou decided to go rogue, hitting themselves with a Skinny Boy Laserita Gun 
Later, Melissa was captured and replaced with a robot by the Anomaly, Arcade and the Super Adaptoid. Restrained in a room with Jodie and Lou, the three were forced to watch M.O.D.O.K. interact with the robot duplicates, making unsuccessful attempts to contact him until M.O.D.O.K. himself was revealed to be a robot built by the real M.O.D.O.K. The robot M.O.D.O.K. self-destructed as the three were freed from their restraints by M.O.D.O.K.'s hacking skills. Jodie, Melissa and Lou then met in Murderworld with M.O.D.O.K., two other versions of the family and their captors. Arcade explained the nature of Murderworld's death game, the Jodie and Lou that Melissa had been locked in with were themselves robots and the true versions of the family needing to kill the robot duplicates to escape; Arcade then disorientated the families so they couldn't tell who they came in with and introduced two robotic duplicates of M.O.D.O.K. Eventually, the family was able to eliminate most of the robot duplicates, with the robots either being killed by the real versions, committing suicide or accidentally killing themselves. The only uncertainty left was the two Lous, who the family decided to spare due to their sweet nature. M.O.D.O.K. goaded the Anomaly into a fight, causing Arcade to leave in protest. The Anomaly ripped out a vital piece of circuitry from M.O.D.O.K., making Jodie retaliate and rip the Anomaly in half. Melissa was able to save M.O.D.O.K's life by re-attaching the piece of circuitry. The family, including the two Lous, went to dinner together. There, the Super Adaptoid came and apologised for betraying the family, causing them to reset him. 
Upon M.O.D.O.K. not inviting any guests to Lou's Bar Mitzvah reception as a result of a misunderstanding, M.O.D.O.K. approached Melissa so she could help recruit teens for it. However, after M.O.D.O.K. ruined Melissa's plan, he decided to bring in guests to the Bar Mitzvah himself. At the Bar Mitzvah, Melissa was upset and used a Skinny Boy Laserita Gun to inebriate herself. A drunken Melissa, encountered Whirlwind, who told her that M.O.D.O.K. has showed videos of her to the Bar with No Name patrons and that he was proud of her for it, causing Melissa's feelings to warm on M.O.D.O.K. After the Super Adaptoid freed two Ciegrimites from their restraints, the Anomaly arrived, the version Jodie had killed having been a robot duplicate, and fired missiles at Melissa and the rest of M.O.D.O.K.'s family. Killing them in an attempt to make his Earth-1226 Counterpart fulfill his dream of ruling the earth. 
Upon taking over the Earth, M.O.D.O.K. vowed to save Melissa and the rest of his family and bring them to his utopia. 
Powers and Abilities
- Ice Skating
- Voiced by Melissa Fumero.
- Melissa was named after Melissa Etheridge.
- During season 1, Melissa is approximately 16 years old.
- 7 appearance(s) of Melissa Tarleton (Earth-1226)
- 5 image(s) of Melissa Tarleton (Earth-1226)
- 1 quotation(s) by or about Melissa Tarleton (Earth-1226)