Loki took the form of Scarlet Witch, and manipulated a new group of Avengers to form in order to embarrass Norman Osborn. The Hulk briefly returned to active duty as an Avenger for the first time since he left the team after having helped found it. Free from Skrull captivity, fellow founder Hank Pym returned to active duty as the new Wasp, struggling to come to terms not only with the post-Civil War world, but with the death of the love of his life, the original Wasp. Two Young Avengers joined the team, the new Vision and Stature, as well as Jocasta, all of whom were results of different aspects of Pym's legacy. The muscle-bound Hercules, Amadeus Cho and US Agent rounded out the roster.
The team gathered at Wundagore Mountain. Iron Man arrived on the scene, hoping to take control of the team. The united forces of the Avengers, aided by who they believed to be Wanda, quashed the threat of Chthon, when he returned by possessing the body of Quicksilver with the help of Modred.. Hank Pym led the team to victory and Quicksilver was freed from his demonic control. 
The Mighty Avengers become an international team by the international organization G.R.A.M.P.A., and were authorized to work outside of the United States. After aiding the team against numerous villains, Quicksilver was accepted as a member. Quicksilver hoped to use the Mighty Avengers to reunite with his sister. In escaping H.A.M.M.E.R. agents, Jocasta inadvertently untethered the "PymPocket" base from reality. Henry Pym contacted Reed Richards, hoping to borrow a device that had been left in the Fantastic Four's care by the late Bill Foster. When Reed refused Pym decided to have his team break into the Baxter Building and steal the device. Pym was successful, and eventually convinced Richards to hand the device over to his Avengers. Pym managed to move the Pym Pocket to a new dimensional location. The degradation of the dimensional gateways required Jocasta to be voluntarily integrated into the system in order to hold it together. The end result was the creation of the Infinite Avengers Mansion, their new base, which would enable them to respond to any crisis.
Quicksilver and U.S. Agent were sent to China to determine a possible alliance between the communist government and the Inhumans. But they soon found out that it is the actually an incursion caused by the exiled Inhuman king known only as the Unspoken. The Unspoken, outcast from his people for removing the Slave Engine and Xerogen Crystals from Attilan, he decided to redeem himself by using the Engine and crystals to convert all of humanity into Alpha Primitives.
Quicksilver attempted to contact his team for help. However, Loki severed communications, fearing that his belief that she was his sister would put a wedge in her plans and hoped that Quicksilver would die. Stature caught her in the act but was magically gagged to prevent her from saying anything bad about "the Scarlet Witch". Therefore, she invited her fellow Young Avengers into the Mansion and tricked them into summoning Loki/Scarlet Witch. Her tolerance for Stature lost, "Wanda" decided to kill them all. However, Clint Barton, the former Hawkeye, had sneaked into the Mansion and determined that Loki was not the Scarlet Witch by kissing her. Loki was forced to flee in order to escape exposure and cast a ward to prevent being summoned again. This canceled out the spell on Stature, who alerted everyone to what's happened in China.
The Mighty Avengers gathered the Avengers Resistance and New Avengers to deal with the Unspoken. They managed to defeat him by turning a chronal ray against him, aging him to the point isn't a threat.
After dealing with civil unrest on the Kree planet Hala, ruled by the Inhumans, the Mighty Avengers returned to Earth, where they continued their global peacekeeping efforts. Their continued achievements overshadowed Osborn, who called together his Cabal to destroy the Mighty Avengers once and for all. Only Loki, back in his male form, responded to the call. He manipulated Osborn into craving more glory. Then, secretly, Loki made one final test for Osborn, by having both Avengers teams pitted against the Absorbing Man. He pulled strings in the fight and portrayed Osborn as a hero, who then uses his authority to strip U.S. Agent of his rank. However, Pym saw him in the crowd. He then set up a machine designed to trap Loki. Quicksilver wanted to divulge the location of his sister Wanda from him, to which the Trickster God answers that he doesn't know, but Quicksilver doesn't believe him. After the arrival of Thor, who was summoned by Loki and explaining that it was his half-brother who was deceiving them, Pym attempted to recruit Loki into the Mighty Avengers. This was the last straw for everyone and thus, the Mighty Avengers disbanded.
Pym, U.S. Agent and Quicksilver joined forces with Hercules, along with the New Avengers, to stop his step-mother Hera's plan to destroy the universe. Unfortunately, when Hercules was seemingly killed trying to save Earth, the impact was so hard on his comrades that they truly went their separate ways, thus finally disbanding the Mighty Avengers. 
- 11 members of Mighty Avengers (Pym) (Earth-616)
- 31 appearance(s) of Mighty Avengers (Pym) (Earth-616)
- 20 image(s) of Mighty Avengers (Pym) (Earth-616)