Miguel O'Hara is an engineer who worked for Alchemax in the year 2099. He was a genius in the field of genetics, but was reluctant when pressured by his higher-ups to imprint foreign genetic codes onto human physiology. After a test resulting in the hideous transformation and then death of the test subject, O'Hara attempted to resign from his position. However, he had a drink laced with a drug that bonds to the victim's DNA. To counteract the drug, he used a procedure to save himself, splicing his DNA with that of a spider, granting him enhanced senses and abilities.

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