Jackal's history is presumably similar to his Earth-616 counterpart's. He was a professor at Capitol State University. One day, he became infatuated with his student Gwen Stacy. Gwen ignored Warren's advances at first, but when they became too much, she asked her adviser to change classes. Instead, the advised and the dean of students confronted Warren and eventually had him fired. With his job and reputation gone, Warren went mad, blaming the college for him not having Gwen.
So, he became the Jackal and burned down old portions of CSU. He was eventually stopped by Gwen as the hero Nightbird and her partner Nighthawk. Warren was imprisoned in Ravencroft Asylum. During a riot at the prison, it was believed that Warren bribed a guard to let him free but then killed the guard before escaping. Later, Warren was captured by Gwen's friend Flash Thompson who was also obsessed with Gwen. To prevent Warren from having Gwen, Flash killed him.