Mister Sinister got his wish fulfilled by the Scarlet Witch as everybody else did during the House of M incident. He was transformed into a seemingly simple man living on a farm. He raised Cable who for an unknown reason in the House of M reality was transformed into an infant.
But as Deadpool, Siryn and Cannonball, entered this reality, Sinister’s evil side started to show. After inviting Deadpool to a barbecue he revealed he had laced the food with drugs so that his “guests” would be easier to study. However, Deadpool was the only one who ate and his healing factor made him virtually immune to the drugs. Sinister then took them to his laboratory in the basement. Subsequently, Mister Sinister’s real plan started to unfold: he wanted to use Cable to become the savior of the world for his evil plans.
Deadpool started a fight with Sinister for baby Cable’s future. Deadpool eventually bodyslid with Cable to his own reality and then the world burned to white once again, thus the House of M disappeared. 
Complete control over his cellular structure. Allowing him to elongate his arms or legs but also giving him a healing factor.
Sinister is a genius geneticist, a brilliant biologist, and a skilled surgeon who is well practiced in the science of cloning.
- 2 Appearances of Nathaniel Essex (Earth-58163)
- 1 Minor Appearances of Nathaniel Essex (Earth-58163)
- Media Nathaniel Essex (Earth-58163) was Mentioned in
- 1 Images featuring Nathaniel Essex (Earth-58163)
- Quotations by or about Nathaniel Essex (Earth-58163)
- Character Gallery: Nathaniel Essex (Earth-58163)
- Mister Sinister (HoM) at marvel.com
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