The Neogenic Recombinator was the result of technological research at Empire State University to harness radiation to perform genetic experiments. The brainchild of Dr. Farley Stillwell and Dr. Curt Connors. They developed a machine capable of utilizing radiation, focused as a coherent beam that was capable of genetic manipulation. It's intended focus was to augment human genetics to treat or alter various characteristics.
During a demonstration of the early prototype machine a spider is caught in the energy beam. Before it dies it bit an on looking student Peter Parker on the hand. The bite transferred the spider's DNA giving Peter spider like powers.
However Neogenics was a still emerging science and fraught with flaws. Doc Connors used the machine on himself in attempt to regrow his arm using lizard DNA whose genetic characteristics allow for regeneration of lost limbs. However the experiment went wrong an he was mutated into the Lizard, Professor Connors was afflicted with the genetic disease for the rest of his life and spent countless times looking for a cure. Later, Stillwell was contracted by J. Jonah Jameson to produce a hero capable of defeating Spider-Man, the result was the Scorpion whose continued rampant severe mutations made him a physical danger and mentally unstable. Stillwell realized Neogenics was too experimental to use on human test subjects yet.
Later on, Dr. Michael Morbius used the technology to study Spider-man's blood but this sample got taken by a vampire bat which in turn bit Morbius turning him into a vampirish creature.
Connors later used the Recombinator as part of Spider-man's genetic treatments in order to stabilize his mutation disease sparing him from turning into the Man-Spider again; however the treatment was a temporary and required a dosage every 24 hours. Ultimately with the battle between Scorpion, the Vulture and Spider-Man, Stillwell was convinced that the technology was too dangerous to use on humanity yet. He overloaded the machinery and began deleting all computer files pertaining to Neogenic research. Connors desperately begged him not to destroy the research; with it being the only means to cure his Lizard mutations; he subsequently transformed and attacked Stillwell only to be handled by a now cured Spider-Man who rescued Connors and Stillwell. With the facility destroyed, after seeing the damage caused by the numerous genetically created villains. Stillwell was the only person with sufficient knowledge to recreate Neogenics successfully and refused to do so; he went into seclusion and was never heard from again. Connors spent the duration to recreate the research.