Nico was just a regular girl when she and her friends realized their parents were part of an evil organization. After learning about that, she and her friends ran away from their parents. During that period Nico learned how to use her magical abilities.
After gathering the information that her mother was once linked to the Masters of the Mystic Arts, Nico decided to contact them to learn more about her mother motivations, in there she became a disciple of the Ancient One.
She was captured alongside her teammates by their former teammate Kaecilius who had turned evil, and used a dimensional rift to summon evil creatures from the Dark Dimension.
Later when the Avengers came to Doctor Strange for help, they freed Nico, and her companions from Kaecilius. After being freed, Nico joined the Avengers Academy.